薛鹏,副教授,硕士生导师,新加坡南洋理工大学博士,重庆市海外引进高层次人才(第四类)。长期从事纳米药物递送系统的设计和开发、癌症的协同治疗和多模态成像诊断、柔性可穿戴微器件平台的构建、以及与生物材料相关交叉学科的研究,积累了多年的研究经验和丰富的研究成果。截至目前,申请人合计发表SCI学术论文74篇(其中第一作者和通讯作者论文43篇),相关研究成果发表于Biomaterials, Theranostics,Nanoscale,ACS Appl. Mater. Interfaces等国际知名SCI期刊。
· 联系方式:
办公电话:023-68253792
电子邮箱:xuepeng@swu.edu.cn
欢迎化学、生物、材料学和电子工程背景的同学报考!
· 学习和工作经历
2005/09–2009/07:哈尔滨工业大学,工学双学士 (电子信息工程,生物工程);
2009/09–2011/07:哈尔滨工业大学,工学硕士 (生物医学工程);
2011/08–2015/12:新加坡南洋理工大学,博士 (生物医学工程);
2015/08–2015/12:新加坡南洋理工大学,研究助理;
2015/12–2016/06:新加坡南洋理工大学,博士后研究员;
2016/06–目前:西南大学,副教授, 硕士生导师。
· 研究方向
1. 刺激响应型低维无机纳米药物制剂研究;
2. 新型肿瘤诊疗技术的开发及应用;
3. 可注射型杂化水凝胶的构建和制备;
4. 医用可穿戴微器件的设计和加工。
· 科研项目
1. 国家自然科学基金青年项目(51703186),2018.01-2020.12,21万,主持。
2. 重庆市技术创新与应用示范项目(cstc2018jscx-msybX0078),2018.07-2020.06,10万,主持。
3. 重庆市留学人员回国创业创新支持计划(cx2018081),2018.07-2020.06,5万,主持。
4. 企事业单位委托横向项目(2016001199),2016.11-2019.11,20万,主持。
5. 中央高校基本科研业务费(XDJK2017C001),2017.01-2018.12,10万,主持。
· 毕业生去向
硕士生
2016级 孙利红 北京大学医学院 读博
2016级 李倩 武汉大学 读博
· 代表性学术论文(近三年)
1. Runjie Ren, Lei Zhang, Jiayi Zhang, Wei Zhang, Yang Cao, Zhigang Xu, Hongjuan Cui, Yuejun Kang, Peng Xue*. “Light-Activated Oxygen Self-Supplied Starving Therapy in Near-Infrared (NIR) Window and Adjuvant Hyperthermia-Induced Tumor Ablation with an Augmented Sensitivity”. Biomaterials, 234, 119771 (2020).
2. Xiaodan Jiao, Wei Zhang, Lei Zhang, Yang Cao, Zhigang Xu, Yuejun Kang, Peng Xue*. “Rational Design of Oxygen Deficient TiO2-x Nanoparticles Conjugated with Chlorin e6 (Ce6) for Photoacoustic Imaging-Guided Photothermal/Photodynamic Dual Therapy of Cancer”. Nanoscale, 12, 1707-1718 (2020).
3. Mengmeng Hou, Weiwei Liu, Lei Zhang, Leiyang Zhang, Zhigang Xu, Yang Cao*, Yuejun Kang, Peng Xue*. “Responsive Agarose Hydrogel Incorporating with Natural Humic Acid and MnO2 Nanoparticles for Effective Relief of Tumor Hypoxia and Enhanced Photo-induced Tumor Therapy”. Biomaterials Science, 8, 353 - 369 (2020).
4. Ya Gao, Mengmeng Hou, Ruihao Yang, Lei Zhang, Zhigang Xu, Yuejun Kang*, Peng Xue*. “Therapeutics transdermal delivery through dissolvable gelatin/sucrose film coated on PEGDA microneedle array with improved skin permeability”. Journal of Materials Chemistry B, 7, 7515 – 7524 (2019).
5. Lihong Sun, Xiaodan Jiao, Weiwei Liu, Ying Wang, Yang Cao, Shu-Juan Bao, Zhigang Xu, Yuejun Kang, Peng Xue*. “Novel Oxygen-Deficient Zirconia (ZrO2−x) for Fluorescence/Photoacoustic Imaging-Guided Photothermal/Photodynamic Therapy for Cancer”. ACS Applied Materials & Interfaces, 11, 41127-41139 (2019).
6. Zhihao Zhou, Yuejun Kang, Zhigang Xu, Peng Xue*. “Development and Prospects of Microfluidic Platforms for Sperm Inspection”. Analytical Methods, 11, 4547-4560 (2019).
7. Ruihao Yang, Mengmeng Hou, Ya Gao, Shiyu Lu, Lei Zhang, Zhigang Xu, Chang Ming Li, Yuejun Kang*, Peng Xue* “Biomineralization-inspired Crystallization of Manganese Oxide on Silk Fibroin Nanoparticles for in vivo MR/fluorescence Imaging-assisted Tri-modal Therapy of Cancer”. Theranostics, 9, 6314-6333 (2019).
8. Lei Zhang, Qian Li, Ruihao Yang, Zhigang Xu, Yuejun Kang, Peng Xue*. “Rapid Prototyping of Nanoroughened Polydimethylsiloxane Surfaces for the Enhancement of Immunomagnetic Isolation and Recovery of Rare Tumor Cells”. Biomedical Microdevices, 21, 58 (2019).
9. Qian Li, Mengmeng Hou, Junjie Ren, Shiyu Lu, Zhigang Xu, Chang Ming Li, Yuejun Kang, Peng Xue*. “Co-delivery of Chlorin e6 and Doxorubicin using PEGylated Hollow Nanocapsules for "All-in-One" Tumor Theranostics”. Nanomedicine (UK), 14, 2273-2292 (2019).
10. Lihong Sun, Qian Li, Lei Zhang, Huihui Chai, Ling Yu, Zhigang Xu, Yuejun Kang, Peng Xue*. “Stimuli Responsive PEGylated Bismuth Selenide Hollow Nanocapsules for Fluorescence/CT imaging and Light-Driven Multimodal Tumor Therapy”. Biomaterials Science, 7, 3025-3040 (2019).
11. Ruihao Yang, Mengmeng Hou, Ya Gao, Lei Zhang, Zhigang Xu, Yuejun Kang*, Peng Xue*. “Indocyanine Green-Modified Hollow Mesoporous Prussian Blue Nanoparticles Loading Doxorubicin for Fluorescence-Guided Tri-Modal Combination Therapy of Cancer”. Nanoscale, 11, 5717 - 5731 (2019).
12. Ya Gao, Mengmeng Hou, Ruihao Yang, Lei Zhang, Zhigang Xu, Yuejun Kang*, Peng Xue*. “Highly Porous Silk Fibroin Scaffold Packed in PEGDA/Sucrose Microneedles for Controllable Transdermal Drug Delivery”. Biomacromolecules, 20, 1334-1345 (2019).
13. Lihong Sun, Mengmeng Hou, Lei Zhang, Dongxiang Qian, Qingquan Yang, Zhigang Xu, Yuejun Kang*, Peng Xue*. “PEGylated Mesoporous Bi2S3 Nanostars Loaded with Chlorin e6 and Doxorubicin for Fluorescence/CT Imaging-Guided Multimodal Therapy of Cancer”. Nanomedicine: Nanotechnology, Biology and Medicine, 17, 1-12 (2019).
14. Qian Li, Lihong Sun, Mengmeng Hou, Qiubing Chen, Ruihao Yang, Lei Zhang, Zhigang Xu, Yuejun Kang*, Peng Xue*. “A Phase-change Material Packaged within Hollow Copper Sulfide Nanoparticles Carrying Doxorubicin and Chlorin e6 for Fluorescence-guided Trimodal Therapy of Cancer”. ACS Applied Materials & Interfaces, 11, 417-429 (2019).
15. Mengmeng Hou, Ruihao Yang, Lei Zhang, Leiyang Zhang, Gang Liu, Zhigang Xu, Yuejun Kang*, Peng Xue*. “Injectable and Natural Humic Acid/Agarose Hybrid Hydrogel for Localized Light-Driven Photothermal Ablation and Chemotherapy of Cancer”. ACS Biomaterials Science & Engineering, 4, 4266–4277 (2018).
16. Ya Gao, Mengmeng Hou, Ruihao Yang, Lei Zhang, Zhigang Xu, Yuejun Kang*, Peng Xue*. “PEGDA/PVP microneedles with tailorable matrix constitutions for controllable transdermal drug delivery”. Macromolecular Materials and Engineering, 303, 1800233 (2018).
17. Peng Xue*, Mengmeng Hou, Lihong Sun, Qian Li, Lei Zhang, Zhigang Xu, Yuejun Kang*. “Calcium-carbonate packaging magnetic polydopamine nanoparticles loaded with indocyanine green for near-infrared induced photothermal/photodynamic therapy”. Acta Biomaterialia, 81, 242-255 (2018).
18. Peng Xue*, Ruihao Yang, Lihong Sun, Qian Li, Lei Zhang, Zhigang Xu, Yuejun Kang*. “Indocyanine Green-Conjugated Magnetic Prussian Blue Nanoparticles for Synchronous Photothermal/Photodynamic Tumor Therapy”. Nano–Micro letters, 10, 74 (2018).
19. Lihong Sun, Qian Li, Mengmeng Hou, Ya Gao, Ruihao Yang, Lei Zhang, Zhigang Xu, Yuejun Kang*, Peng Xue*. “Light-activatable Chlorin e6 (Ce6)-imbedded Erythrocyte Membrane Vesicles Camouflaged Prussian Blue Nanoparticles for Synergistic Photothermal and Photodynamic Therapies of Cancer”. Biomaterials Science, 6, 2881-2895 (2018).
20. Peng Xue, Lei Zhang, Zhigang Xu, Junjie Yan, Zhen Gu*, Yuejun Kang*. “Blood Sampling Using Microneedles as a Minimally Invasive Platform for Biomedical Diagnostics”. Applied Materials Today, 13, 144-157 (2018).
21. Lei Zhang, Lihong Sun, Mengmeng Hou, Zhigang Xu, Yuejun Kang*, Peng Xue*. “A paper-based photothermal array using Parafilm to analyze hyperthermia response of tumour cells under local gradient temperature”. Biomedical Microdevices, 20, 68 (2018).
22. Lei Zhang, Zhigang Xu, Yuejun Kang*, Peng Xue*. “Three-Dimensional microfluidic chip with twin-layer herringbone structure for high efficient tumor cell capture and release via antibody-conjugated magnetic microbeads”. Electrophoresis, 39(12), 1452-1459 (2018).
23. Qian Li, Lihong Sun, Lei Zhang, Zhigang Xu, Yuejun Kang*, Peng Xue*. “Polydopamine-collagen complex to enhance the biocompatibility of polydimethylsiloxane substrates for sustaining long-term culture of L929 fibroblasts and tendon stem cells”. Journal of Biomedical Materials Research Part A, 106, 408-418 (2018).
24. Lihong Sun, Qian Li, Lei Zhang, Zhigang Xu, Yuejun Kang*, Peng Xue*. “PEGylated Polydopamine Nanoparticles Incorporated with Indocyanine Green and Doxorubicin for Magnetically-guided Multimodal Cancer Therapy Triggered by Near-infrared Light”. ACS Applied Nano Materials, 1, 325-336 (2018).
25. Peng Xue*, Qian Li, Lihong Sun, Lei Zhang, Zhigang Xu, Chang Ming Li, Yuejun Kang*. “A simple technique of constructing nano-roughened polydimethylsiloxane surface to enhance mesenchymal stem cell adhesion and proliferation”. Microfluidics and Nanofluidics, 22, 1 (2018).
26. Peng Xue*, Lihong Sun, Qian Li, Lei Zhang, Zhigang Xu, Chang Ming Li, Yuejun Kang*. “PEGylated magnetic Prussian blue nanoparticles as a multifunctional therapeutic agent for combined targeted photothermal ablation and pH-triggered chemotherapy of tumour cells”. Journal of colloid and interface science, 509, 384-394 (2018).
27. Shuang Bai, Yong-E Gao, Xiaoqian Ma, Xiaoxiao Shi, Meili Hou, Peng Xue*, Yuejun Kang*, Zhigang Xu*. “Reduction stimuli-responsive unimolecular polymeric prodrug based on amphiphilic dextran-framework for antitumor drug delivery”. Carbohydrate polymers, 182, 235-244 (2018).
28. Peng Xue*, Lihong Sun, Qian Li, Lei Zhang, Jinhong Guo, Zhigang Xu, Yuejun Kang*. “PEGylated polydopamine-coated magnetic nanoparticles for combined targeted chemotherapy and photothermal ablation of tumour cells”. Colloids and Surfaces B: Biointerfaces, 160, 11-21 (2017).
29. Peng Xue*, Qian Li, Yuan Li, Lihong Sun, Lei Zhang, Zhigang Xu, Yuejun Kang*. “Surface Modification of Poly (dimethylsiloxane) with Polydopamine and Hyaluronic Acid To Enhance Hemocompatibility for Potential Applications in Medical Implants or Devices”. ACS Applied Materials & Interfaces, 9, 33632-33644 (2017).
30. Zhigang Xu*#, Peng Xue#, Yonge Gao, Shiying Liu, Xiaoxiao Shi, Meili Hou, Yuejun Kang*. “pH-responsive polymeric micelles based on poly(ethyleneglycol)-b-poly(2-(diisopropylamino) ethyl methacrylate) block copolymer for enhanced intracellular release of anticancer drugs”. Journal of Colloid and Interface Science. 490, 511-519 (2017).